A 55-yr old male with biopsy, confirmed with adenocarcinoma of the colon, was admitted for surgery. The patient had been bleeding into the GI tract for the past 10 days. The medical history was significant for epistaxis and hypertension. The nosebleeds lasted more than 12 minutes but require no medical treatment. The patient states that he bleeds a lot from cuts, but wounds heal normally. He is unaware of family history of bleeding. The physician ordered a PT, PTT and CBC. Test Result Reference Range WBC count 11.2 x 10^9/L 4-11 x 10^9/L RBC count 3.22 x 10^12/L 4.50-5.50 x 10^12/L HGB 10.2 g/dl 12-15 g/dl HCT 31.6% 35-45% MCV 98 fl 80-99 fl MCH 31 pg 25-32 pg MCHC 32.8% 32-36% PLT 166 x 10^9/L 150-450 x 10^9/L Differential Differential Differential Segmented Neutrophils 53% 50-70% Bands 8% 0-5% Lymphs 27% 20-40% Monos 7% 2-10% Eos 4% 2-4% Metamyelocytes 1% 0% PB smear Normocytic normochromic with slight anisocytosis Normocytic Normochromic with slight anisocytosis Given the positive BAT result, coagulation tests were ordered, and the results are below: Test Result Reference Range PT/INR 11.6 sec 10-14 sec INR 1.5 2.5-3.5 APTT 46 sec 23-35 sec Please answer the questions below: List all the significant findings of this case (both in the clinical presentation and in the laboratory values) and explain why they are significant. There are at least 5 in each category (clinical presentation and laboratory values). Based on the clinical and laboratory presentation of this case, what diseases are you suspecting. Name at least 2 disorders that you suspect. What lab tests would you run to confirm one disorder and rule out the rest of the suspecting disorders? Predict the laboratory values on the confirmatory tests that will support your final diagnosis? What is your final diagnosis? Propose a pathophysiologic mechanism of this disease that produced the provided results. View keyboard shortcuts EditViewInsertFormatToolsTable 12pt Paragraph