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(Solved): A recent transgenic mouse was created in which the Atg8 gene was selectively inactivated in central ...



A recent transgenic mouse was created in which the Atg8 gene was selectively inactivated in central nervous system neurons. How many of the following phenotypes would you expect to observe in these mice? progressive neurodegeneration; high cholesterol levels in the blood; undigested glycolipids accumulating in neuronal lysosomes; the accumulation of protein aggregates and damaged mitochondria in neurons; the absence of ubiquitinated mitochondria in neurons; undigested LDL particles accumulating in neuronal lysosomes



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