(Solved): b) Shown below are the structures of three benzodiazepines - lorazepam, oxazepam and temazepam - an ...

b) Shown below are the structures of three benzodiazepines - lorazepam, oxazepam and temazepam - and the reverse-phase UHPLC separation of these drugs and their respective glucuronides (from Phase II metabolism). Temazenam IJILUvim Describe the principles of HPLC and then explain the benefits of UHPLC versus traditional HPLC. c) Identify and explain which group of peaks (1-3 or 4-6) in the chromatogram corresponds to the glucuronide metabolites and which group corresponds to the drug molecules. Which peak in the chromatogram corresponds to temazepam and why?