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(Solved): Draw the products of the two step reaction sequence shown below. Use dash and/or wedge bonds to ind ...
Draw the products of the two step reaction sequence shown below. Use dash and/or wedge bonds to indicate stereochemistry where appropriate.
1. CH3?CH2?MgBr 2. H3?O+ Select to Draw PBr3? DMF Select to Draw
The nucleophilic addition of Grignard reagent according to Cram's rule.When the alpha carbon of carbonyl is chiral and have three groups attached i.e. large, medium and small group then according to Cram's rule the attack of nucleophile to the carbonyl will takes place from the side of small group but the compound should be arranged in eclipsed form.