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(Solved): Patients with von Gierke's disease (type I glycogen storage disease) have a deficiency of glucose-6- ...



Patients with von Gierke's disease (type I glycogen storage disease) have a deficiency of glucose-6-phosphatase. One of the most prominent symptoms of the disease is a protruding abdomen due to an enlarged liver. Explain why the liver is enlarged in patients with von Gierke's disease. (select all that apply)

A. Glycogen breakdown is increased in the liver of patients with von Gierke's disease so that increased release of glucose is used for fat synthesis.
B. Glycogen synthesis is elevated in the livers of patients with this disease.
C. In the absence of this enzyme, glucose accumulates in the liver and is converted to glucose-1-phosphate, which is used for glycogen synthesis.
D. The accumulation of glycogen enlarges the liver and causes the abdomen to protrude.
E. In the absence of this enzyme, glycogen cannot be stored in the liver and so glucose is converted to fat in the liver making it enlarged.


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