Problem 4: 8 points Rage 3 is found to be a mutational target of the rombie form of Rage 1. Its normal sequence is as follows:
N^(')
- WEEKEERIMNAMADFACERAEMAIIDAD-C' (4 points) RAGE1 mutates 3 key residues in RAGE3, allowing it to fold into a stable colled coll with four heptad repeats. Circle the sites that are most likely mutated and propose mutations that are possible to give this effect. (4 points) In which pH range would this form a stable helax?