(Solved): Review: Amino acids Amino acid side chains act as nucleophiles and proton donors/acceptors in vario ...

Review: Amino acids Amino acid side chains act as nucleophiles and proton donors/acceptors in various enzymatic reactions. We will use them frequently in reactions during 40B and therefore the purpose of this exercise is to review the properties of amino acid side chains you have learned in 40A. Additionally, you will practice working with a large chemical structure.... 1. Tirzepatide is an antidiabetic medication used for the treatment of type 2 diabetes and for weight loss. It is sold under the brand name Mounjaro and Zepbound. The following figure shows the partial structure of the drug. a. Circle all atoms originating in the amino acid Lys. What is the functional group of the side chain? b. Box all atoms originating in the amino Asp. Check if there is more than one. c. Draw the structure of His and the values of the pKa of all its functional groups (Place a number close to the functional group). d. The protonation state of each functional group depends on the pH of the solution. Assume that the above molecule is in a solution at \( \mathrm{pH}=7.4 \). Draw the missing functional groups in their correct protonation state based on their pKa.