Time left 0:24:10Select the correct statement/statements regarding the signaling pathways involved in hormone action mediated by cell membrane receptors.I. Water-soluble hormones directly affect the transcription of target genes by binding to intracellular hormonereceptors.11. Steroid hormones bind to receptors located on the extracellular surface of the cell membrane and initiate a signaling cascade involving second messengers.III Not all water-soluble hormones initiate the cAMP second messenger system.IV. The action of phosphodiesterase (PDE) ensures prolonged activation of the CAMP second messenger system by preventing the degradation of CAMP.Select onea II & IIIb. I & IIOnly IIId. I & IV